Mantle Cell Lymphomas Lack Expression of p27kip1, a Cyclin-Dependent Kinase Inhibitor
نویسندگان
چکیده
منابع مشابه
Expression of cyclin-dependent kinase inhibitor p27kip1 in malignant lymphomas.
p27kip1 is a cyclin-dependent kinase inhibitor that regulates progression from G1 into S phase. Aberrations in cell cycle control are often observed in tumors and might even be necessary in tumor development. Recent reports showed that low p27kip1 expression is associated with poor prognosis in several tumors and leukemia. To investigate the expression of p27kip1 in malignant lymphomas and eluc...
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Cyclin E and the cyclin-dependent kinase inhibitor p27 are two important regulators of the G1-S transition modulating the activity of cyclin-dependent kinases. Aberrations in the cell cycle control are often observed in tumors and might even be mandatory in tumor development. To investigate the importance of cell-cycle defects in malignant lymphomas we have characterized the expression of cycli...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 1998
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)65558-7